Section 2 - Composition, Information on Ingredients

CAS#	Chemical Name	Percent	EINECS/ELINCS
50-78-2	Acetylsalicylic acid (aspirin)	100	200-064-1

Section 3 - Hazards Identification

Appearance: white powder.
Warning! Toxic. May cause severe eye irritation and possible injury. Harmful if swallowed. May cause skin and respiratory tract irritation.
Target Organs: Blood.


Potential Health Effects
Eye: May cause eye irritation and possible burns. Burns to the eyes and scarring can occur.
Skin: May cause skin irritation. May be absorbed through the skin in harmful amounts. Low hazard for usual industrial handling.
Ingestion: Harmful if swallowed. May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause central nervous system depression. May cause allergic reaction. May interfere with blood clotting. Inhibits platelet aggregation affecting bleeding time. High or repeated exposure may cause headache, dizziness, depression and irritability. If an allergic response develops, later exposures to even very small amounts can cause hives, difficulty breathing, and/or rapid drop in blood pressure.
Inhalation: May cause respiratory tract irritation. Can produce anaphylactic shock with even small doses.
Chronic: Chronic ingestion may result in salicylism which is characterized by nausea, vomiting, gastrointestinal ulcers, and hemorrhagic strokes. May cause fetal effects based on animal studies. Whether or not acetaylsalicylic acid (aspirin) is a human teratogen is controversial. There is no conclusive evidence that salicylates are teratogenic in humans.

Section 4 - First Aid Measures

Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid imme diately.
Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion: Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Get medical aid.
Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician: Treat symptomatically and supportively.

Section 5 - Fire Fighting Measures

General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or appropriate foam.
Flash Point: Not available.
Autoignition Temperature: Not available.
Explosion Limits, Lower:Not available.
Upper: Not available.
NFPA Rating: (estimated) Health: 2; Flammability: 0; Instability: 0

Section 6 - Accidental Release Measures

General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions.

Section 7 - Handling and Storage

Handling: Wash thoroughly after handling. Use with adequate ventilation. Avoid contact with skin and eyes. Avoid ingestion and inhalation.
Storage: Store in a cool, dry place. Store in a tightly closed container.

Section 8 - Exposure Controls, Personal Protection

Engineering Controls: Good general ventilation should be sufficient to control airborne levels. Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower.
Exposure Limits

Chemical Name	ACGIH	NIOSH	OSHA - Final PELs
Acetylsalicylic acid (aspirin)	5 mg/m3 TWA	5 mg/m3 TWA	none listed

OSHA Vacated PELs: Acetylsalicylic acid (aspirin): 5 mg/m3 TWA
Personal Protective Equipment
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin: Wear appropriate protective gloves to prevent skin exposure.
Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - Physical and Chemical Properties

Physical State: Powder
Appearance: white
Odor: odorless
pH: Not available.
Vapor Pressure: Not applicable.
Vapor Density: Not available.
Evaporation Rate:Not applicable.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point:136 - 140 deg C
Decomposition Temperature:Not available.
Solubility: 2.5 G/L (15°C)
Specific Gravity/Density:Not available.
Molecular Formula:C9H8O4
Molecular Weight:180.16

Section 10 - Stability and Reactivity

Chemical Stability: Stable.
Conditions to Avoid: Dust generation.
Incompatibilities with Other Materials: Strong oxidizing agents, strong bases, strong acids, Hydrolyzes in moist air, decomposes in hot water..
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported.

Section 11 - Toxicological Information

RTECS#:      
CAS# 50-78-2: VO0700000
LD50/LC50:
CAS# 50-78-2:
     Oral, mouse: LD50 = 250 mg/kg;
     Oral, rabbit: LD50 = 1010 mg/kg;
     Oral, rat: LD50 = 200 mg/kg;
.

Carcinogenicity:
CAS# 50-78-2: Not listed by ACGIH, IARC, NTP, or CA Prop 65.

Epidemiology: Epidemiological evidence has suggested the possibility of an association between the use of aspirin in the treatment of fever in children with chickenpox or influenza virus infections and the development of Reye's Syndrome.
Teratogenicity: Teratogenic effects have occurred in experimental animals.Whether or not aspirin is a human teratogen is controversial. Some studies have linked prenatal aspirin exposure with cardiac effects, but it has not been confirmed by other studies. The possibility of a weak teratogenic effect has not been conclusively ruled out however.
Reproductive Effects: See actual entry in RTECS for complete information.
Mutagenicity: Aspirin induced chromosome aberrations in cultured human fibrolasts.Mutagenic effects have occurred in experimental animals.
Neurotoxicity: No information found
Other Studies:

Section 12 - Ecological Information

No information available.

Section 13 - Disposal Considerations

Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3. Additionally, waste generators must consult state and local hazardous waste regulations to ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: None listed.

Section 14 - Transport Information

	US DOT	Canada TDG
Shipping Name:	TOXIC SOLIDS, ORGANIC, N.O.S.	TOXIC SOLID ORGANIC NOS (ACETYLSALICYLIC ACID)
Hazard Class:	6.1	6.1
UN Number:	UN2811	UN2811
Packing Group:	III	III

Section 15 - Regulatory Information

US FEDERAL

TSCA
     CAS# 50-78-2 is listed on the TSCA inventory.
Health & Safety Reporting List
     None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
     None of the chemicals in this product are under a Chemical Test Rule.
Section 12b
     None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
     None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
     None of the chemicals in this material have an RQ.
SARA Section 302 Extremely Hazardous Substances
     None of the chemicals in this product have a TPQ.
Section 313      No chemicals are reportable under Section 313.
Clean Air Act:
     This material does not contain any hazardous air pollutants.
     This material does not contain any Class 1 Ozone depletors.
     This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
     None of the chemicals in this product are listed as Hazardous Substances under the CWA.
     None of the chemicals in this product are listed as Priority Pollutants under the CWA.
     None of the chemicals in this product are listed as Toxic Pollutants under the CWA.
OSHA:
     None of the chemicals in this product are considered highly hazardous by OSHA.
STATE
     CAS# 50-78-2 can be found on the following state right to know lists: California, New Jersey, Pennsylvania, Minnesota, Massachusetts.

California Prop 65
The following statement(s) is(are) made in order to comply with the California Safe Drinking Water Act:
WARNING: This product contains Acetylsalicylic acid (aspirin), a chemical known to the state of California to cause female reproductive toxicity.
California No Significant Risk Level: None of the chemicals in this product are listed.

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols:
     T
Risk Phrases:
     R 25 Toxic if swallowed.

Safety Phrases:
     S 45 In case of accident or if you feel unwell, seek medical advice
     immediately (show the label where possible).
     S 28A After contact with skin, wash immediately with plenty of water
     .

WGK (Water Danger/Protection)
     CAS# 50-78-2: 1
Canada - DSL/NDSL
     CAS# 50-78-2 is listed on Canada's DSL List.
Canada - WHMIS
     This product has a WHMIS classification of D1B, D2B.
This product has been classified in accordance with the hazard criteria of the Controlled Products Regulations and the MSDS contains all of the information required by those regulations.
Canadian Ingredient Disclosure List

Section 16 - Additional Information

MSDS Creation Date: 12/12/1997
Revision #4 Date: 11/23/2004

The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall Fisher be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if Fisher has been advised of the possibility of such damages.